双气体纳米粒体外杀伤肿瘤细胞的实验研究开题报告

1. 研究目的与意义（文献综述包含参考文献）

1. current status of cancer

cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018. globally, about 1 in 6 deaths is due to cancer. approximately 70% of deaths from cancer occur in low- and middle-income countries. late-stage presentation and inaccessible diagnosis and treatment are common. in 2017, only 26% of low-income countries reported having pathology services generally available in the public sector. more than 90% of high-income countries reported treatment services are available compared to less than 30% of low-income countries.the economic impact of cancer is significant and is increasing. the total annual economic cost of cancer in 2010 was estimated at approximately us$ 1.16 trillion (4).cancer arises from the transformation of normal cells into cancer cells in a multistage process that generally progresses from a pre-cancerous lesion to a malignant cancer. therefore, it is urgent to develop easy and effective cancer treatments

2.cancer treatments

2. 研究的基本内容、问题解决措施及方案

1. co-deliver oxygen and no to enhance pdt for cancer treatment

2. incubate nanoparticles with 4t1 breast cancer cells and detect the cell viability of cancer cells.

3. use fluorescence dyes to evaluate the concentration of no in cancer cells